Diro Kesakhian was the boss of an Armenian Mafia family. She was once a young college girl and devout Orthodox Christian.
After Shane Vendrell was booted from the Strike Team by Vic Mackey, he took to moonlighting as an enforcer for Diro and her dying father. After Shane uncovered the names of three African-Americans who were robbing the Kesakhians' stable of Russian hookers, Diro arranged for the trio to be castrated. Vic, however, attempted to drive a wedge between Diro and Shane by revealing his stormy past with Antwon Mitchell. Panicking when Diro attempted to end their arrangement, Shane told her that Vic and Ronnie robbed the Money Train. To his horror, Diro responded by putting out contracts on Vic, Ronnie, and their families. When Shane pleaded with her to leave the families out of it, Diro coldly responded, "We can't leave the people we love out of the choices we make."
Shane disabled the hitman sent to kill Vic's family by shooting him in the stomach; he also kidnapped Vic's family to protect them from being killed. He also transferred his allegiance to Ellis Rezian, her main rival. Ellis put out a hit on Diro and her father, but Shane warned her so that she could escape before she was killed.
Diro was forced to flee to Germany, where she had been attending college, but not before she euthanized her father. Before catching her flight, she told Shane, "Your sentiment will destroy you."